The Simpsons - Season 13 Episode 19 : The Sweetest Apu
Homer and Marge discover that Apu is having an affair with the Squishee delivery lady at the Kwik-E-Mart. They decide to keep Apu's wife Manjula from finding out about it. However, she eventually learns of Apu's affair by watching store security tapes. She throws Apu out of the house and decides to file for divorce, but soon realizes that she misses him.